Lung Cancer Risk Reduction & Prevention

By Pierre P. Massion, MD Posted: October 2018 Early detection is key to disease management. For example, there are numerous data in hypertension, diabetes, coronary artery disease, and renal dysfunction showing strong correlation between early diagnosis and improved outcome.1 Noninvasive means of early detection of cancer is around the corner.2-4 Recent research has positioned the…

By John K. Field, PhD, and Matthijs Oudkerk, MD, PhD Lung cancer kills more Europeans than any other cancer. In 2014, 272,000 citizens of the twenty-eight countries in the European Union (EU) died from lung cancer, which is 20.1% of all cancer deaths.1 When implemented in the general population, lung cancer screening using CT saves…

Posted: June 2017 By Bernard Milleron, MD, and Sébastien Couraud, MD, PhD Large-scale lung cancer screening trials have been successfully conducted in several countries, and formal screening recommendations have been made based on this key research. For example, the U.S. National Lung Screening Trial (NLST) demonstrated in 2011 that annual screening by low-dose computed tomography…

Posted: June 2017 By John K. Field, PhD, FRCPath and James L. Mulshine, MD, PhD There is now robust and consistent evidence for the cost-effectiveness of lung cancer computed tomography (CT) screening as delineated in the recent analysis from ten Haaf and colleagues in PLOS Medicine.1 They have used microsimulation modeling analysis based on the…

Posted: April 2017 By James L. Mulshine, MD, PhD and John K. Field, PhD, FRCPath Administration (VHA) clinicians reported their experience in implementing lowdose computed tomography (CT) lung cancer screening at 8 VHA hospitals.1 In this experience, 2,106 subjects were screened from July 2013 to June 30, 2015, which resulted in the diagnosis of 31…

Posted: February 2017 By John K. Field, PhD, FRCPath, and James L. Mulshine, MD, PhD The Fourth IASLC Screening Strategy Advice Committee (SSAC) computed tomography (CT) screening workshop was held on December 3, 2016, prior to IASLC WCLC 2016. This workshop provided a comprehensive international forum for all lung cancer clinical specialties to meet and…

By Denise R. Aberle, MD The seminal National Lung Screening Trial (NLST) showed that lung cancer screening using low dose computed tomography (LDCT) resulted in a 20% decrease in lung cancer mortality relative to chest radiography in older, heavy smokers. Additionally, there was a relative 6.7% decrease in all-cause mortality (due largely to improved lung…

By Gerard A. Silvestri, MD, MS, FCCP A recent population-based study suggested the incidence of pulmonary nodules detected by CT is around 1.5 million per year. This finding is no surprise given the increasing use of chest CT for myriad of medical conditions and may increase even further as lung cancer screening is implemented nationally.…

By James L. Mulshine, MD, PhD, Fred Hirsch, MD, PhD, and John K. Field, PhD, FRCPath Over the last fifteen years, the use of lowdose computed tomography (LDCT) for early lung cancer detection in high-risk individuals has moved from the seminal study arising from an NIH-funded R01 grant,1 to the publication of the validation results…

By Prof. Fabien Calvo, MD, PhD Today, cancer research is facing several challenges. The genomics era has ushered in a host of new molecular therapies; however, most of these targeted agents work for a limited subset of patients. Pooling data among centers, to analyze which sequences and combination of treatments perform best for which type…