ILCN Lung Cancer News
ILCN Lung Cancer News


  • TRK Inhibition in TRK Fusion–Positive Lung Cancers

    TRK Inhibition in TRK Fusion–Positive Lung Cancers

    Evolving Standards of Care

    By Alexander Drilon, MD Posted: February 12, 2020 The receptor tyrosine kinases TRKA/B/C are encoded by the genes NTRK1/2/3. TRK fusions are oncogenic drivers of various adult and pediatric cancers. These fusions are found at high frequencies (> 90% in select series) in rare cancers such as secretory carcinoma and at lower frequencies in more…