By Denise R. Aberle, MD The seminal National Lung Screening Trial (NLST) showed that lung cancer screening using low dose computed tomography (LDCT) resulted in a 20% decrease in lung cancer mortality relative to chest radiography in older, heavy smokers. Additionally, there was a relative 6.7% decrease in all-cause mortality (due largely to improved lung…

By Gerard A. Silvestri, MD, MS, FCCP A recent population-based study suggested the incidence of pulmonary nodules detected by CT is around 1.5 million per year. This finding is no surprise given the increasing use of chest CT for myriad of medical conditions and may increase even further as lung cancer screening is implemented nationally.…

By James L. Mulshine, MD, PhD, Fred Hirsch, MD, PhD, and John K. Field, PhD, FRCPath Over the last fifteen years, the use of lowdose computed tomography (LDCT) for early lung cancer detection in high-risk individuals has moved from the seminal study arising from an NIH-funded R01 grant,1 to the publication of the validation results…

By Prof. Fabien Calvo, MD, PhD Today, cancer research is facing several challenges. The genomics era has ushered in a host of new molecular therapies; however, most of these targeted agents work for a limited subset of patients. Pooling data among centers, to analyze which sequences and combination of treatments perform best for which type…