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  • Pembrolizumab Plus Platinum-Doublet Chemotherapy and Concurrent Radiotherapy as First-Line Treatment for Unresectable, Locally Advanced Stage III NSCLC: The KEYNOTE-799 Trial in Perspective

    Pembrolizumab Plus Platinum-Doublet Chemotherapy and Concurrent Radiotherapy as First-Line Treatment for Unresectable, Locally Advanced Stage III NSCLC: The KEYNOTE-799 Trial in Perspective

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    Noemí Reguart, et al.
    Evolving Standards of Care

    Approximately one-third of patients with NSCLC are diagnosed with unresectable, locally advanced (LA) stage III disease.1 Historically, the standard of care for these patients has been concurrent platinum-based chemotherapy with definitive thoracic radiation therapy (cCRT), 2 garnering a median OS of approximately 28 months and 5-year OS rates of 15% to 30%, at best. The…

  • Comprehensive Analysis of Proteomics Identifies New, Druggable Drivers of NSCLC—and New Avenue for Continued Research

    Comprehensive Analysis of Proteomics Identifies New, Druggable Drivers of NSCLC—and New Avenue for Continued Research

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    Evolving Standards of Care

    Despite the past decade’s accomplishments in identifying the genetic drivers of NSCLC, the complexity of these cancers continues to create barriers to effective targeted treatment. Finding strategies capable of overcoming those barriers will depend, in part, on the in-depth study of the proteins whose activity causes oncogenicity, according to Ramaswamy Govindan, MD, a medical oncologist…

  • Toward More Inclusive, Accessible Clinical Trial Consent Forms

    Toward More Inclusive, Accessible Clinical Trial Consent Forms

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    Patient Advocacy

    It is a trend many years in the making, but the time is ripe to fix the increasing problems with clinical trial consent documentation. The word count and complexity of mandated information in informed consent forms have been multiplying, but their value remains dubious. In 2016, Danish researchers studying consent forms found that “a considerable…

  • Therapeutic Vaccine Development in Lung Cancer: Update and Recent Advances

    Therapeutic Vaccine Development in Lung Cancer: Update and Recent Advances

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    Mohamad Omar Ashi, et al.
    Evolving Standards of Care

    Most cancer immunotherapies currently in development aim to stimulate antitumor T-cell responses either by adoptive transfer of in vitro expanded native or genetically modified T lymphocytes targeting malignant cells,1 ,2  administration of neutralizing monoclonal antibodies (mAb) specific to T-cell inhibitory receptors, such as cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) and programmed death-1 (PD-1),3 ,4 ,5 ,6 ,7…

  • Radiotherapy Inaccessibility in Lung Cancer Care: An Ongoing Crisis

    Radiotherapy Inaccessibility in Lung Cancer Care: An Ongoing Crisis

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    Federico Maldonado Magos, et al.
    Radiation Oncology

    A leading cause of mortality worldwide, cancer was tied to nearly 10 million deaths in 2020.1 Lung cancer has remained unchallenged for more than 30 years as the most commonly diagnosed malignancy and the leading cause of cancer mortality worldwide, accounting for up to 1.8 million deaths per year.2 ,3 Treatment for lung cancer depends…

  • Economics of Locally Advanced Lung Cancer Before and During COVID-19 Pandemic: A Perspective for Developing Countries

    Economics of Locally Advanced Lung Cancer Before and During COVID-19 Pandemic: A Perspective for Developing Countries

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    Andrés F. Cardona, et al.
    Evolving Standards of Care

    Since December 2019, the world has been mired in a pandemic that has displaced other 21st-century health priorities for many populations. The social significance and speed of contagion from COVID-19 have altered criteria for public health prioritization, to the detriment of other health problems including noncommunicable diseases, which are recognized as the leading cause of…

  • More Than a Partnership: How Oncogene-Driven Patient Groups Are Mobilizing the Global Community to Drive Research

    More Than a Partnership: How Oncogene-Driven Patient Groups Are Mobilizing the Global Community to Drive Research

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    Upal Basu Roy
    Patient Advocacy & Survivorship

    It has been just over a year since we reported how oncogene-driven patient advocacy groups are disrupting the research paradigm in lung cancer.1 We have indeed come a long way since the discovery of the first EGFR mutation in lung cancer in 2004.2 ,3 Even amid the challenges of the global COVID-19 pandemic, the lung…

  • Transbronchial Microwave Ablation of Malignant Lung Nodules: Outcomes, Challenges, and Perspective

    Transbronchial Microwave Ablation of Malignant Lung Nodules: Outcomes, Challenges, and Perspective

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    Joyce W.Y. Chan, et al.
    Surgical Oncology

    With increasing availability of CT scans and strong evidence for the utility of low-dose CT screening in high-risk populations,1 an increasing number of small lung nodules are being incidentally discovered. Many are small, subsolid, and may harbor premalignant or early-stage tumors. Local treatment of early primary lung cancers and lung oligometastases is gaining popularity, especially…

  • The IASLC Language Guide: A Lexicon of Healing for Lung Cancer and Beyond

    The IASLC Language Guide: A Lexicon of Healing for Lung Cancer and Beyond

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    Patient Advocacy

    America’s decades-long war on smoking has been remarkably successful in reducing smoking rates, but the unintended consequences include stigmatizing people who smoke and people with lung cancer. Sadly, those dealing with lung cancer continually encounter hurtful statements born of ignorance or thoughtlessness (questions such as, “Do you smoke?”), along with the burden of having to…

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