ILCN Lung Cancer News
ILCN Lung Cancer News


  • TRACERx Data Show That Tracking MRD With ctDNA Heralds Disease Relapse

    TRACERx Data Show That Tracking MRD With ctDNA Heralds Disease Relapse

    Meeting News

    By Kara Nyberg, PhD Posted: June 24, 2020 New findings from the TRACERx lung study underscore the value of using circulating tumor DNA (ctDNA) to predict NSCLC relapse postsurgery based on the detection of minimal residual disease (MRD). Moreover, the results appear sufficiently robust to begin to support use of ctDNA as a biomarker for…


  • PASSION Results Support Further Study of Camrelizumab Plus Apatinib in SCLC

    PASSION Results Support Further Study of Camrelizumab Plus Apatinib in SCLC

    Meeting News

    By Kara Nyberg, PhD Posted: June 24, 2020 The phase II PASSION trial sought to explore the potential synergy between immunotherapy and antiangiogenic drug therapy previously observed in preclinical studies. As reported at AACR, the trial showed that combined second-line treatment with camrelizumab, a PD-1 inhibitor, and apatinib, a VEGFR2 inhibitor, demonstrated promising antitumor activity…


  • Prior Pneumonitis as a Risk Factor for Treatment-Associated Pneumonitis With Immune Checkpoint Inhibitor
            Therapy

    Prior Pneumonitis as a Risk Factor for Treatment-Associated Pneumonitis With Immune Checkpoint Inhibitor Therapy

    Meeting News

    By Kara Nyberg, PhD Posted: June 24, 2020 Pneumonitis is a well-known complication associated with immune checkpoint inhibitors (ICI). A collaborative effort between the U.S. Food and Drug Administration (FDA) and Synapse, a consultancy firm, retrospectively analyzed both clinical trial data and real-world data (RWD) taken from the Advocate Aurora Health System to elucidate risk…


  • Single-Agent Pembrolizumab Active Against STK11- and KEAP1- Mutated NSCLC According to KEYNOTE-042
            Analysis

    Single-Agent Pembrolizumab Active Against STK11- and KEAP1- Mutated NSCLC According to KEYNOTE-042 Analysis

    Meeting News

    By Kara Nyberg, PhD Posted: June 24, 2020 Genomic alterations in STK11 and KEAP1 represent two of the most common and potent contributors to a cold tumor immune microenvironment in nonsquamous NSCLC. Although prior research has shown that these mutations are tied to poor outcomes in patients treated with immune checkpoint blockade, particularly in the…


  • TERAVOLT: Global Registry Investigates Outcomes Among Patients With Thoracic Cancer and COVID-19

    TERAVOLT: Global Registry Investigates Outcomes Among Patients With Thoracic Cancer and COVID-19

    Uncategorized

    By Marina Chiara Garassino, MD, and Leora Horn, MD, MSc, FRCPC Posted: June 9, 2020   Marina Chiara Garassino       Leora Horn   The new SARS-CoV-2 (COVID-19) virus appeared at the end of December 2019 in Wuhan, China, and soon spread globally. In February 2020, the first cases appeared in Europe, and in…


  • Key Findings from the CAR T-Cell Study Presented at the 2019 AACR Annual Meeting

    Key Findings from the CAR T-Cell Study Presented at the 2019 AACR Annual Meeting

    Evolving Standards of Care

    By Prasad S. Adusumilli, MD, FACS, FCCP Posted: November 12, 2019 My colleagues and I conducted a phase I clinical trial of mesothelin-targeted chimeric antigen receptor (CAR) T-cell therapy in patients with malignant pleural disease from mesothelioma and metastatic lung or breast cancer, and we presented the findings at the 2019 American Association for Cancer…