Timely and relevant thoracic oncology news brought to you by the only global association dedicated to the multidisciplinary study of lung cancer.

Timely and relevant thoracic oncology news brought to you by the only global association dedicated to the multidisciplinary study of lung cancer.


Clinical Trial Design


  • Timing is of the Essence: Commentary on NRG/Alliance LU005 Results

    Timing is of the Essence: Commentary on NRG/Alliance LU005 Results

    By

    Haleigh Behrman
    Clinical Trial Design, Immunotherapy

    While the trial did not yield a survival benefit, Dr. Adam Schoenfeld says the study strengthens the case that immunotherapy timing and sequencing matter.


  • Phase II Trial Evaluates Amivantamab Plus Lazertinib in EGFR-Mutant Lung Cancers With New or Progressing Brain Metastases or Leptomeningeal Disease

    Phase II Trial Evaluates Amivantamab Plus Lazertinib in EGFR-Mutant Lung Cancers With New or Progressing Brain Metastases or Leptomeningeal Disease

    By

    Haleigh Behrman
    Clinical Trial Design, Diagnostic Oncology

    In addition to encouraging intracranial activity and survival outcomes, Dr. Mark Jeng details how the findings highlight the limitations of current LMD assessment tools and demonstrate the feasibility of conducting prospective trials within this population.


  • What Do Recent ODAC Decisions Mean for Lung Cancer Drug Development and Clinical Trial Design?

    What Do Recent ODAC Decisions Mean for Lung Cancer Drug Development and Clinical Trial Design?

    By

    Haleigh Behrman
    Clinical Trial Design, Evolving Standards of Care

    In a Q&A with ILCN, Dr. John V. Heymach addresses several rulings from the Oncologic Drugs Advisory Committee and important lessons for research teams.


  • IASLC Studying Impact of COVID-19 on International Lung Cancer Clinical Trial Enrollment, Mitigation
            Strategies

    IASLC Studying Impact of COVID-19 on International Lung Cancer Clinical Trial Enrollment, Mitigation Strategies

    By

    Clinical Trial Design

    Although clinical trials are vitally important to researchers working to improve therapies for lung cancer, clinical trials also provide what could be lifesaving treatments to those patients on trials. When there is a disruption to the clinical trial pipeline—anything from funding to barriers to in-person site visits for treatments and follow up exams— lung cancer…


  • Cancer Clinical Trial Compensation: Undue or Long Overdue?

    Cancer Clinical Trial Compensation: Undue or Long Overdue?

    By

    Clinical Trial Design

    When compensating participants in clinical trials, the objective is to show appreciation and consideration for a patient’s time and expenses without exerting undue influence. The Office for Human Research Protections of the U.S. Department of Health and Human Services (HHS) defines undue influence as a potential consequence of an “offer of an excessive or inappropriate…


  • Revised U.S. Food and Drug Administration Trial Eligibility Guidance: A Major Step Toward Transforming
            Lung Cancer Clinical Trials

    Revised U.S. Food and Drug Administration Trial Eligibility Guidance: A Major Step Toward Transforming Lung Cancer Clinical Trials

    By

    David E. Gerber, MD, et al.
    Clinical Trial Design

    By now, investigators, sponsors, clinicians, and patients are widely aware of the crisis facing cancer clinical trials. With scientific discoveries occurring more rapidly than ever, there is a growing need to bring novel therapies to patients as efficiently as possible. Yet, in the United States, fewer than 3% of adults with cancer enroll in clinical…