Tarlatamab Emerges as New Standard of Care in Second-Line SCLC, with Significant Gains in OS, PFS
Joy CurzioDr. Charles M. Rudin, who presented data from the DeLLphi-304 trial at ASCO 2025, noted that patient-reported outcomes also showed improvements in common symptoms, including dyspnea and cough, with fewer toxicities of grade 3 or higher. Read more
A Paradigm Shift: Final 5-Year Overall Survival Results from CheckMate 816 in Resectable NSCLC
Haleigh BehrmanDr. Patrick Forde recently presented milestone data from the trial that confirms the benefit of neoadjuvant-only chemoimmunotherapy for the treatment of resectable lung cancer. Read more
Research to Watch: FDA Grants ZL-1310 Fast Track Designation for Extensive-Stage SCLC
Haleigh BehrmanZL-1310 earns Fast Track Designation as a potential first-in-class DLL3-targeted ADC for extensive-stage small cell lung cancer. Read more
In Brief for June 25, 2025
Haleigh BehrmanThe US FDA recently granted approval to taletrectinib for ROS1-positive NSCLC and accepted a priority review for lurbinectedin plus atezolizumab for ES-SCLC in the first-line setting. Read more
Lurbinectedin and Atezolizumab Combo Demonstrates Survival Benefit in ES-SCLC
Haleigh BehrmanDr. Luis G. Paz-Ares reviewed new IMforte trial results at the 2025 ASCO Annual Meeting. Read more
Early Data Suggest that a 14-Gene Molecular Assay May Help Predict Recurrence Risk in Patients with Early-Stage Non-Squamous NSCLC
Haleigh BehrmanAuthor Dr. David Spigel says these findings may pave the way for more accurate, biomarker-guided decisions for lung cancer treatment after surgery. Read more
In Brief for June 11, 2025
Haleigh BehrmanVENTANA MET (SP44) RxDx Assay receives FDA approval as a companion diagnostic for telisotuzumab vedotin-tllv in patients with high c-MET overexpression in NSCLC. Read more
Overcoming Resistance Remains a Challenge in Targeting KRAS
Haleigh BehrmanDana-Farber's Dr. Alice Shaw recently explored various combination strategies that show promise in preventing or delaying resistance in this previously undruggable space. Read more
Immune Checkpoint Inhibitors in NSCLC: Do Survival Benefits End if Treatment Does?
Haleigh BehrmanDrs. Mark Awad and Federica Pecci said recent findings suggest some patients with non-small cell lung cancer may experience survival benefits and disease control even after stopping ICI treatment. Read more
Research to Watch: CAN-2409 Demonstrates Survival Benefit in Patients with Advanced NSCLC Unresponsive to ICIs
Haleigh BehrmanAccording to recent phase II data, the experimental treatment demonstrated a median overall survival of 24.5 months. Read more