ADRIATIC Demonstrates Meaningful Improvements in OS, PFS in Patients with Limited-stage SCLC
Erin JungmeyerAs the first study to establish the role of immunotherapy in this setting, Dr. David R. Spigel says consolidation durvalumab will become the new standard of care for this population. Read more
Glecirasib Shows Promise in Treating Advanced Lung Cancer Harboring KRAS G12C Mutations
Erin JungmeyerWith only 5% of patients stopping treatment due to treatment-related adverse events, lead author Yuankai Shi, MD, says glecirasib may help improve patient compliance with oral therapy. Read more
Mounting Evidence Supporting Neoadjuvant ChemoIO Means Surgeons Must Adapt
Ke-Neng Chen, MDIn a two-part commentary, Dr. Ke-Neng Chen discusses how surgeons must adjust in light of recent clinical trials, beginning with a discussion of the challenges of TNM staging. Read more
More Than Ever, Surgeons Must Collaborate to Ensure Patients Receive Appropriate Care
Ke-Neng Chen, MDAs thoracic surgery in the management of NSCLC evolves, Dr. Ke-Neng Chen highlights the importance of avoiding unnecessary treatments and using a multidisciplinary approach. Read more
A New Treatment Option for Early-Stage ALK+ NSCLC: Adjuvant Alectinib
Narjust Florez, MDIn part 2 of their interview, Drs. Narjust Florez and Benjamin Solomon dig deeper into the implications of the ALINA trial, discussing endpoints, toxicities, and future directions. Read more
Increased Biomarker Uptake Needed to Further Realize Potential of Precision Medicine
Christian Rolfo, MD, PhD, MBA, Drhc+more
Drs. Christian Rolfo and Valeria Denninghoff contend that data show improvements in outcomes from personalized treatment may have stalled and that increased testing for driver genes alterations is needed. Read more
Could Precision Oncology Evolve to Treat Cancer Before It Develops?
Laila C. Roisman, PhD+more
Drs. Laila Roisman and Nir Peled envision a future where artificial intelligence elevates personalized medicine in ways once thought impossible. Read more
Challenges of Systemic Therapy for Patients with EGFR-mutated Lung Cancer After Progression on Targeted Therapy
Christi M.J. Steendam, MD, PhD+more
Drs. Christi M.J. Steendam and Sushil K. Badrising review studies comparing outcomes of various treatment regimens in the search for the best-performing approach. Read more
No PFS, OS Benefit Seen in Final Results from PACIFIC-2
Erin JungmeyerDr. Jeffrey D. Bradley presented the data from the phase III study of durvalumab in combination with and following chemoradiotherapy for patients with unresectable, stage III NSCLC during the 2024 European Lung Cancer Congress. Read more
MARIPOSA-2 Post-progression Analysis Favors Amivantamab-Chemotherapy Combination
Erin JungmeyerCompared to chemotherapy alone, the addition of the EGFR-MET bispecific antibody significantly prolonged progression-free survival after subsequent therapy, said Dr. Ryan Gentzler during the European Lung Cancer Congress. Read more