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Home Evolving Standards of Care

LAURA Trial Defines Role of EGFR-directed Therapy in Unresectable Stage III NSCLC

Erin Jungmeyer
on: June 11, 2024In: Evolving Standards of Care, Meeting News
LAURA Trial Defines Role of EGFR-directed Therapy in Unresectable Stage III NSCLC

Primary results from the study, presented by Dr. Suresh Ramalingam, showed osimertinib offers a significant improvement in progression-free survival following chemoradiotherapy. Read more


ADRIATIC Demonstrates Meaningful Improvements in OS, PFS in Patients with Limited-stage SCLC

Erin Jungmeyer
on: June 11, 2024In: Evolving Standards of Care, Meeting News
ADRIATIC Demonstrates Meaningful Improvements in OS, PFS in Patients with Limited-stage SCLC

As the first study to establish the role of immunotherapy in this setting, Dr. David R. Spigel says consolidation durvalumab will become the new standard of care for this population. Read more

Glecirasib Shows Promise in Treating Advanced Lung Cancer Harboring KRAS G12C Mutations

Erin Jungmeyer
on: June 11, 2024In: Evolving Standards of Care
Glecirasib Shows Promise in Treating Advanced Lung Cancer Harboring KRAS G12C Mutations

With only 5% of patients stopping treatment due to treatment-related adverse events, lead author Yuankai Shi, MD, says glecirasib may help improve patient compliance with oral therapy. Read more

Mounting Evidence Supporting Neoadjuvant ChemoIO Means Surgeons Must Adapt

Ke-Neng Chen, MD
on: May 21, 2024In: Evolving Standards of Care
Mounting Evidence Supporting Neoadjuvant ChemoIO Means Surgeons Must Adapt

In a two-part commentary, Dr. Ke-Neng Chen discusses how surgeons must adjust in light of recent clinical trials, beginning with a discussion of the challenges of TNM staging. Read more

More Than Ever, Surgeons Must Collaborate to Ensure Patients Receive Appropriate Care

Ke-Neng Chen, MD
on: May 21, 2024In: Evolving Standards of Care
More Than Ever, Surgeons Must Collaborate to Ensure Patients Receive Appropriate Care

As thoracic surgery in the management of NSCLC evolves, Dr. Ke-Neng Chen highlights the importance of avoiding unnecessary treatments and using a multidisciplinary approach. Read more

A New Treatment Option for Early-Stage ALK+ NSCLC: Adjuvant Alectinib

Narjust Florez, MD
on: May 21, 2024In: Evolving Standards of Care
A New Treatment Option for Early-Stage ALK+ NSCLC: Adjuvant Alectinib

In part 2 of their interview, Drs. Narjust Florez and Benjamin Solomon dig deeper into the implications of the ALINA trial, discussing endpoints, toxicities, and future directions. Read more

Increased Biomarker Uptake Needed to Further Realize Potential of Precision Medicine

Christian Rolfo, MD, PhD, MBA, Drhc
+more
on: May 07, 2024In: Evolving Standards of Care
Increased Biomarker Uptake Needed to Further Realize Potential of Precision Medicine

Drs. Christian Rolfo and Valeria Denninghoff contend that data show improvements in outcomes from personalized treatment may have stalled and that increased testing for driver genes alterations is needed. Read more

Could Precision Oncology Evolve to Treat Cancer Before It Develops?

Laila C. Roisman, PhD
+more
on: May 07, 2024In: Evolving Standards of Care
Could Precision Oncology Evolve to Treat Cancer Before It Develops?

Drs. Laila Roisman and Nir Peled envision a future where artificial intelligence elevates personalized medicine in ways once thought impossible. Read more

Challenges of Systemic Therapy for Patients with EGFR-mutated Lung Cancer After Progression on Targeted Therapy

Christi M.J. Steendam, MD, PhD
+more
on: April 23, 2024In: Evolving Standards of Care
Challenges of Systemic Therapy for Patients with EGFR-mutated Lung Cancer After Progression on Targeted Therapy

Drs. Christi M.J. Steendam and Sushil K. Badrising review studies comparing outcomes of various treatment regimens in the search for the best-performing approach. Read more

No PFS, OS Benefit Seen in Final Results from PACIFIC-2

Erin Jungmeyer
on: April 23, 2024In: Evolving Standards of Care
No PFS, OS Benefit Seen in Final Results from PACIFIC-2

Dr. Jeffrey D. Bradley presented the data from the phase III study of durvalumab in combination with and following chemoradiotherapy for patients with unresectable, stage III NSCLC during the 2024 European Lung Cancer Congress. Read more

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MARIPOSA OS Data Confirms Improved Efficacy for Amivantamab Plus Lazertinib in the First Line for EGFR-mutated NSCLC

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