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Investigators Report Efficacy, Safety Analysis of Tarlatamab in SCLC Patients With or Without Baseline Brain Metastases

John Austin
on: July 09, 2024In: Evolving Standards of Care, Meeting News
Investigators Report Efficacy, Safety Analysis of Tarlatamab in SCLC Patients With or Without Baseline Brain Metastases

Dr. Anne-Marie C. Dingemans said the data indicate that it is safe to prescribe tarlatamab for these patients now that it has been approved by the US FDA. Read more


Data Look Promising for First-line Sotorasib, Platinum-based Chemotherapy Combination for KRAS-mutant NSCLC

Fred Gebhart
on: July 09, 2024In: Evolving Standards of Care, Meeting News
Data Look Promising for First-line Sotorasib, Platinum-based Chemotherapy Combination for KRAS-mutant NSCLC

Presenter Dr. Bob T. Li said further study is needed, particularly given the positive PFS results in PDL-1-negative patients, who represent an unmet medical need. Read more

CROWN Results Demonstrate Longest Progression-Free Survival in Advanced NSCLC Seen to Date

Erin Jungmeyer
on: June 25, 2024In: Evolving Standards of Care, Meeting News
CROWN Results Demonstrate Longest Progression-Free Survival in Advanced NSCLC Seen to Date

When presenting the data, Dr. Benjamin Solomon said first-line lorlatinib offers unprecedented improvement in outcomes for patients with advanced ALK+ non-small cell lung cancer. Read more

Subcutaneous Amivantamab Leads to Unexpected OS Improvement vs. IV Dosing in Refractory, EGFR+ Advanced NSCLC

Fred Gebhart
on: June 25, 2024In: Evolving Standards of Care, Meeting News
Subcutaneous Amivantamab Leads to Unexpected OS Improvement vs. IV Dosing in Refractory, EGFR+ Advanced NSCLC

Dr. Natasha Leighl said the findings of PALOMA-3 show subcutaneous dosing offers other advantages, including reduced adverse events. Read more

KRYSTAL-12 Supports Previous Evidence Showing Adagrasib is Superior to Docetaxel in Pretreated Advanced KRAS-mutated NSCLC

Fred Gebhart
on: June 25, 2024In: Evolving Standards of Care, Meeting News
KRYSTAL-12 Supports Previous Evidence Showing Adagrasib is Superior to Docetaxel in Pretreated Advanced KRAS-mutated NSCLC

Dr. Tony Mok said the results of the phase III KRYSTAL-12 trial reinforce adagrasib as an effective second-line treatment option for this patient population. Read more

LAURA Trial Defines Role of EGFR-directed Therapy in Unresectable Stage III NSCLC

Erin Jungmeyer
on: June 11, 2024In: Evolving Standards of Care, Meeting News
LAURA Trial Defines Role of EGFR-directed Therapy in Unresectable Stage III NSCLC

Primary results from the study, presented by Dr. Suresh Ramalingam, showed osimertinib offers a significant improvement in progression-free survival following chemoradiotherapy. Read more

ADRIATIC Demonstrates Meaningful Improvements in OS, PFS in Patients with Limited-stage SCLC

Erin Jungmeyer
on: June 11, 2024In: Evolving Standards of Care, Meeting News
ADRIATIC Demonstrates Meaningful Improvements in OS, PFS in Patients with Limited-stage SCLC

As the first study to establish the role of immunotherapy in this setting, Dr. David R. Spigel says consolidation durvalumab will become the new standard of care for this population. Read more

MARIPOSA-2 Post-progression Analysis Favors Amivantamab-Chemotherapy Combination

Erin Jungmeyer
on: April 23, 2024In: Evolving Standards of Care, Meeting News
MARIPOSA-2 Post-progression Analysis Favors Amivantamab-Chemotherapy Combination

Compared to chemotherapy alone, the addition of the EGFR-MET bispecific antibody significantly prolonged progression-free survival after subsequent therapy, said Dr. Ryan Gentzler during the European Lung Cancer Congress. Read more

Can Artificial Intelligence Identify Those at High Risk and Shift the Lung Cancer Screening Paradigm?

Erin Jungmeyer
on: April 23, 2024In: Evolving Standards of Care, Meeting News
Can Artificial Intelligence Identify Those at High Risk and Shift the Lung Cancer Screening Paradigm?

In a recent interview, Dr. Lecia V. Sequist, a member of the team behind the Sybil AI algorithm, discusses how technology may soon be able to predict who will develop lung cancer. Read more

FLAURA 2 Post-progression Outcomes Demonstrate Consistent Benefit, Favor Combination Arm

Erin Jungmeyer
on: April 09, 2024In: Evolving Standards of Care, Meeting News
FLAURA 2 Post-progression Outcomes Demonstrate Consistent Benefit, Favor Combination Arm

During the European Lung Cancer Congress, Dr. Natalia Valdiviezo presented the data, which favored frontline osimertinib plus chemotherapy compared to osimertinib alone for patients with EGFR-mutated NSCLC. Read more

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MARIPOSA OS Data Confirms Improved Efficacy for Amivantamab Plus Lazertinib in the First Line for EGFR-mutated NSCLC

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